Linked Life Data

819359

Source:http://linkedlifedata.com/resource/pubmed/id/819359

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1976-8-23
pubmed:abstractText
Studies were made on the rate of phagocytosis and killing of Pseudomonas aeruginosa by phagocytic cells in the peritoneal cavity of rabbits. In sublethal and lethal infections the phagocytosed bacteria were killed very quickly. In antibody-protected animals, the polymorphs became loaded with liveing bacteria, but this had little effect on the decline in infection. In sublethal infections and in protected animals theproportion of intracellular bacteria labelled with 32O or [14C]uracil was high and antibody greatly enhanced phagocytosis. In lethal infections the rate of phagocytosis was insufficient to prevent the development of a fatal septicaemia. Antipolymorphonuclear leucocyte serum (APS) completely suppressed the normal polymorph response to infection and greatly reduced resistance. The macrophages in the peritoneum, which were not affected by APS, delayed bacterial growth for several hours but were eventually unable to control bacterial mutiplication. The outcome of infection appeared to depend almost entirely on the ratio of bacterial to phagocytes and the presence of antibody. Iron-binding proteins probably make a significant contribution to resistance by reducing the rate of multiplication of extracellular bacteria.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
603-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
The effect of antipolymorphonuclear leucocyte serum on Pseudomonas aeruginosa infection in rabbits.
pubmed:publicationType
Journal Article