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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1994-6-22
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pubmed:abstractText |
Two hundred sixty-three pediatric patients from the ages of 3 months to 11 years were enrolled in a randomized, investigator-blinded, multicenter study comparing the clinical and bacteriological efficacies and safety of cefuroxime axetil suspension (CAE) with those of amoxicillin-clavulanate suspension (AMX-CL) in the treatment of acute otitis media with effusion. Patients received CAE at 30 mg/kg of body weight per day (n = 165) in two divided doses or AMX-CL at 40 mg/kg/day (n = 98) in three divided doses for 10 days. The primary pathogens among 200 isolates from pretreatment cultures of middle ear fluid were identified as follows: Haemophilus influenzae (39%), over a third of which were beta-lactamase positive; Streptococcus pneumoniae (34%); and Moraxella catarrhalis (16%). Pathogens were eradicated or presumed to be eradicated from 81% (95 of 118) and 76% (50 of 66) of bacteriologically evaluable patients in the CAE and AMX-CL groups, respectively. A satisfactory clinical response (cure or improvement with or without resolution of effusion) occurred in 113 (77%) of 146 clinically evaluable patients in the CAE group and in 66 (74%) of 89 evaluable patients in the AMX-CL group. Clinical failure or recurrence (within 2 weeks following the completion of treatment) occurred in 22 and 26% of CAE- and AMX-CL-treated patients, respectively. Drug-related adverse events occurred in 18% of CAE-treated patients, whereas they occurred in 39% of AMX-CL-treated patients (P < 0.001); diarrhea or loose stools was the most commonly reported adverse event (CAE, 12%; AMX-CL, 31%; P < 0.001). These results indicate that CAE given twice daily is as effective as AMX-CL given three times daily in the treatment of acute otitis media with effusion in pediatric patients, but CAE was associated with significantly fewer drug-related adverse events.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-1617076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-2187594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-2218657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-2406100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-2648288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-3064037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-3534203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-3554125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-3696838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-4039433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8192458-8452344
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin-Potassium Clavulanate...,
http://linkedlifedata.com/resource/pubmed/chemical/Cefuroxime,
http://linkedlifedata.com/resource/pubmed/chemical/Clavulanic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs,
http://linkedlifedata.com/resource/pubmed/chemical/Suspensions,
http://linkedlifedata.com/resource/pubmed/chemical/cefuroxime axetil
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0066-4804
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8192458-Amoxicillin,
pubmed-meshheading:8192458-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:8192458-Cefuroxime,
pubmed-meshheading:8192458-Child,
pubmed-meshheading:8192458-Child, Preschool,
pubmed-meshheading:8192458-Clavulanic Acids,
pubmed-meshheading:8192458-Female,
pubmed-meshheading:8192458-Humans,
pubmed-meshheading:8192458-Infant,
pubmed-meshheading:8192458-Male,
pubmed-meshheading:8192458-Otitis Media with Effusion,
pubmed-meshheading:8192458-Prodrugs,
pubmed-meshheading:8192458-Suspensions
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pubmed:year |
1994
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pubmed:articleTitle |
Comparison of cefuroxime axetil and amoxicillin-clavulanate suspensions in treatment of acute otitis media with effusion in children.
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pubmed:affiliation |
Scottsdale Pediatrics, Arizona 85260.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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