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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1994-6-21
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pubmed:abstractText |
We have previously shown that IL-6 is a major cytokine in the serum of mice infected with the intracellular bacterium Listeria monocytogenes, and that injection of rIL-6 before, but not after, infection promotes the recovery of mice from listeriosis. Here we demonstrate that IL-6 is required in the early stages of infection, in that injection of anti-IL-6 Ab 24 or 4 h before infection, but not 24 h after, led to a massive increase in bacterial numbers 4 or more days after infection. On the other hand, injection of rIL-6 before infection significantly suppressed bacterial numbers in the liver and spleen 3 to 4 days after infection and increased the production of IFN-gamma by in vitro cultured CD4+ and CD8+ T cells in response to specific Ag. rIL-6 did not protect SCID mice, which lack both T and B lymphocytes, against Listeria infection. The protective effect of rIL-6 was neutralized by the injection of Ab to IFN-gamma. We conclude that IL-6 plays an essential role in the activation of T cells to produce IFN-gamma, the cytokine that is central to acquired cellular resistance to intracellular bacteria.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5375-80
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8189056-Animals,
pubmed-meshheading:8189056-Antibodies, Monoclonal,
pubmed-meshheading:8189056-Female,
pubmed-meshheading:8189056-Interferon-gamma,
pubmed-meshheading:8189056-Interleukin-4,
pubmed-meshheading:8189056-Interleukin-6,
pubmed-meshheading:8189056-Listeria monocytogenes,
pubmed-meshheading:8189056-Listeriosis,
pubmed-meshheading:8189056-Lymphocyte Activation,
pubmed-meshheading:8189056-Mice,
pubmed-meshheading:8189056-Mice, Inbred BALB C,
pubmed-meshheading:8189056-Mice, Inbred C57BL,
pubmed-meshheading:8189056-Mice, SCID,
pubmed-meshheading:8189056-Recombinant Proteins,
pubmed-meshheading:8189056-T-Lymphocytes
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pubmed:year |
1994
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pubmed:articleTitle |
Role of IL-6 in activation of T cells for acquired cellular resistance to Listeria monocytogenes.
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pubmed:affiliation |
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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