| pubmed-article:8188716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8188716 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8188716 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8188716 | lifeskim:mentions | umls-concept:C0812265 | lld:lifeskim |
| pubmed-article:8188716 | lifeskim:mentions | umls-concept:C0597718 | lld:lifeskim |
| pubmed-article:8188716 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:8188716 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:8188716 | pubmed:dateCreated | 1994-6-22 | lld:pubmed |
| pubmed-article:8188716 | pubmed:abstractText | ErbB3 is a member of the epidermal growth factor (EGF) receptor subfamily of receptor tyrosine kinases and is believed to be a receptor for an unknown ligand. We have tested the possibility that heregulin, a growth factor possessing an EGF-like domain, is a ligand for ErbB3. We have found that the iodinated recombinant EGF-like domain of heregulin-beta 1 (125I-rHRG beta 1(177-244) bound specifically to insect cell-expressed bovine ErbB3 with a dissociation constant of 0.85 nM. Moreover, 125I-rHRG beta 1(177-244) bound to NIH3T3 fibroblasts stably transfected with bovine erbB3 with a dissociation constant of 60 pM, but did not bind to parental cells. 125I-rHRG beta 1(177-244) could be chemically cross-linked to a 170-180 kDa protein in erbB3-transfected fibroblasts, and the cross-linked product could be immunoprecipitated with antibodies specific for ErbB3. Finally, rHRG beta 1 stimulated the tyrosine phosphorylation of both ErbB3 and endogenous p185erbB2/neu in transfectants but not in parental cells. We conclude that ErbB3 is a receptor for HRG and is capable of mediating HRG-stimulated tyrosine phosphorylation of itself and p185erbB2/neu in cells that express both receptors. | lld:pubmed |
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| pubmed-article:8188716 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8188716 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8188716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8188716 | pubmed:month | May | lld:pubmed |
| pubmed-article:8188716 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:CantleyL CLC | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:VandlenR LRL | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:SliwkowskiM... | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:PlatkoJ VJV | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:CerioneR ARA | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:CarrawayK... | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:GuyP MPM | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:AkitaRR | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:NuijensAA | lld:pubmed |
| pubmed-article:8188716 | pubmed:author | pubmed-author:DiamontiA JAJ | lld:pubmed |
| pubmed-article:8188716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8188716 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:8188716 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:8188716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8188716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8188716 | pubmed:pagination | 14303-6 | lld:pubmed |
| pubmed-article:8188716 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8188716 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8188716 | pubmed:articleTitle | The erbB3 gene product is a receptor for heregulin. | lld:pubmed |
| pubmed-article:8188716 | pubmed:affiliation | Department of Cell Biology, Harvard Medical School, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:8188716 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8188716 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8188716 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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