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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-6-21
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pubmed:databankReference |
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pubmed:abstractText |
The gene for human aminomethyltransferase (AMT), also known as the T-protein of the glycine cleavage system, was isolated from a human placental cosmid library and examined by restriction mapping, polymerase chain reaction analysis, and DNA sequencing. The gene is about 6 kb in length and consists of nine exons. The 5'-flanking region of the gene lacks typical TATAA sequence but has a single defined transcription initiation site detected by the primer extension method. Two putative glucocorticoid-responsive elements and a putative thyroid hormone-responsive element are present. The AMT gene was assigned to subband 3p21.2-p21.1 by fluorescence in situ hybridization.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8188235-Amino Acid Metabolism, Inborn Errors,
pubmed-meshheading:8188235-Aminomethyltransferase,
pubmed-meshheading:8188235-Base Sequence,
pubmed-meshheading:8188235-Chromosome Mapping,
pubmed-meshheading:8188235-Chromosomes, Human, Pair 3,
pubmed-meshheading:8188235-Exons,
pubmed-meshheading:8188235-Genes,
pubmed-meshheading:8188235-Glycine,
pubmed-meshheading:8188235-Humans,
pubmed-meshheading:8188235-Hydroxymethyl and Formyl Transferases,
pubmed-meshheading:8188235-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8188235-Molecular Sequence Data,
pubmed-meshheading:8188235-Multienzyme Complexes,
pubmed-meshheading:8188235-Polymerase Chain Reaction,
pubmed-meshheading:8188235-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:8188235-Transferases
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pubmed:year |
1994
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pubmed:articleTitle |
Structure and chromosomal localization of the aminomethyltransferase gene (AMT)
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pubmed:affiliation |
Department of Pediatrics, Akita University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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