Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-6-23
|
| pubmed:abstractText |
NADPH-diaphorase histochemistry was combined with demonstration of acetylcholinesterase and immunocytochemistry for calcitonin gene-related peptide to study esophageal innervation in the rat. Most of the myenteric neurons stained positively for NADPH-diaphorase, as did numerous varicose nerve fibers in the myenteric plexus, among striated muscle fibers, around arterial blood vessels, and in the muscularis mucosae. A majority of motor endplates (as demonstrated by acetylcholinesterase histochemistry or calcitonin gene-related peptide immunocytochemistry) were associated with fine varicose NADPH-diaphorase-positive nerve fibers. Analysis of brainstem nuclei, sensory vagal, spinal, and sympathetic ganglia in normal and neonatally capsaicin-treated rats, and comparison with anterogradely labeled vagal branchiomotor, preganglionic and sensory fibers led to the conclusion that NADPH-diaphorase-positive fibers on motor endplates originate in esophageal myenteric neurons. No association of NADPH-diaphorase-positive nerve fibers with motor endplates was found in other organs containing striated muscle. These results suggest extensive, presumably nitrergic, co-innervation of esophageal striated muscle fibers by enteric neurons. Thus, control of peristalsis in the esophagus of the rat may be more complex than hitherto assumed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0302-766X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
276
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-30
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8187163-Acetylcholinesterase,
pubmed-meshheading:8187163-Animals,
pubmed-meshheading:8187163-Brain Stem,
pubmed-meshheading:8187163-Calcitonin Gene-Related Peptide,
pubmed-meshheading:8187163-Capsaicin,
pubmed-meshheading:8187163-Esophagus,
pubmed-meshheading:8187163-Female,
pubmed-meshheading:8187163-Ganglia, Sensory,
pubmed-meshheading:8187163-Ganglia, Sympathetic,
pubmed-meshheading:8187163-Immunohistochemistry,
pubmed-meshheading:8187163-Intestine, Small,
pubmed-meshheading:8187163-Motor Endplate,
pubmed-meshheading:8187163-Muscle, Smooth,
pubmed-meshheading:8187163-NADPH Dehydrogenase,
pubmed-meshheading:8187163-Nerve Fibers,
pubmed-meshheading:8187163-Neurons,
pubmed-meshheading:8187163-Rats,
pubmed-meshheading:8187163-Rats, Wistar
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
NADPH-diaphorase-positive nerve fibers associated with motor endplates in the rat esophagus: new evidence for co-innervation of striated muscle by enteric neurons.
|
| pubmed:affiliation |
Institute of Anatomy, University of Zürich, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|