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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1994-6-22
|
| pubmed:abstractText |
Enhanced expression of beta-adrenoceptor densities on peripheral blood mononuclear cells (PBMCs) in progressive multiple sclerosis patients has been observed in a number of independent studies. A link between increased number of beta-adrenoceptors and inflammatory disease has been further indicated by studies in rheumatoid arthritis and relapsing-remitting multiple sclerosis patients. In a serial monthly assessment of relapsing-remitting multiple sclerosis patients, we have demonstrated that increased beta-adrenoceptors on PBMCs correlate with the expression of high affinity interleukin-2 receptors (IL-2Rs) and disease activity as determined by clinical and MRI findings. Magnetic resonance imaging activity was strongly correlated with IL-2R expression and it appears to be a sensitive marker of PBMC immunoactivation in multiple sclerosis. In vitro studies showed that beta-agonist stimulation of PBMCs reduces the IL-2R expression and suppresses cell proliferation following mitogenic stimulation. This observation may indicate a recovery role for the enhanced beta-adrenoceptor expression in multiple sclerosis. However, its therapeutic importance remains to be tested by appropriate trials using either beta-agonists or agents activating the second messenger system, c-AMP, in lymphocytes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-8950
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
117 ( Pt 2)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
307-15
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8186957-Adult,
pubmed-meshheading:8186957-Female,
pubmed-meshheading:8186957-Humans,
pubmed-meshheading:8186957-Leukocytes, Mononuclear,
pubmed-meshheading:8186957-Magnetic Resonance Imaging,
pubmed-meshheading:8186957-Male,
pubmed-meshheading:8186957-Middle Aged,
pubmed-meshheading:8186957-Mitogens,
pubmed-meshheading:8186957-Multiple Sclerosis,
pubmed-meshheading:8186957-Receptors, Adrenergic, beta,
pubmed-meshheading:8186957-Receptors, Interleukin-2
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Increased expression of high affinity IL-2 receptors and beta-adrenoceptors on peripheral blood mononuclear cells is associated with clinical and MRI activity in multiple sclerosis.
|
| pubmed:affiliation |
Multiple Sclerosis Laboratory, National Hospital for Neurology and Neurosurgery, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|