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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1994-6-23
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pubmed:abstractText |
An economic analysis of the oral antifungal drugs griseofulvin (GRI), ketoconazole (KET), and terbinafine (TER), currently registered and used in treating onychomycosis of fingernails and toenails, was performed using a model that incorporates elements of both meta-analysis and pharmacoeconomics. The meta-analysis of published studies determined rates of success, relapse and side-effects. The perspective taken for the analysis was that of the government payer, with expected total cost and cost-effectiveness being calculated. A multiphase approach was used. The studies of onychomycosis of the fingernails showed that TER had a 95.0% success rate, KET 80.9%, and GRI 59.6%. GRI had the lowest acquisition costs. The success rates for onychomycosis of the toenails were: TER 78.3%, KET 40.8%, and GRI 17.5%. GRI had the lowest acquisition costs. However, expected cost comparison showed TER had the lowest cost because of shorter treatment duration. The expected cost of therapy with a 100% government payer perspective for fingernail onychomycosis was the lowest for TER ($439.83), followed by GRI ($480.80), then KET ($755.46). Toenail onychomycosis showed the same order for the comparators, with TER $1049.77, GRI $1388.54 and KET $1936.48. When compared with TER, fingernail cost-effectiveness ratios for GRI and KET were 1.51 and 2.00. Toenail cost-effectiveness ratios were 2.49 and 2.48, respectively. For both fingernail and toenail onychomycosis, TER had the greatest number of disease-free days (973 for fingernails; 1073 for toenails), followed by KET (837; 798), then GRI (702; 569).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Griseofulvin,
http://linkedlifedata.com/resource/pubmed/chemical/Ketoconazole,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/terbinafine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0963
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
130 Suppl 43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8186140-Antifungal Agents,
pubmed-meshheading:8186140-Canada,
pubmed-meshheading:8186140-Cost-Benefit Analysis,
pubmed-meshheading:8186140-Foot Dermatoses,
pubmed-meshheading:8186140-Griseofulvin,
pubmed-meshheading:8186140-Hand Dermatoses,
pubmed-meshheading:8186140-Humans,
pubmed-meshheading:8186140-Ketoconazole,
pubmed-meshheading:8186140-Naphthalenes,
pubmed-meshheading:8186140-Onychomycosis
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pubmed:year |
1994
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pubmed:articleTitle |
Cost-effectiveness analysis for onychomycosis therapy in Canada from a government perspective.
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pubmed:affiliation |
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Meta-Analysis
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