Linked Life Data

8185294

Source:http://linkedlifedata.com/resource/pubmed/id/8185294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-6-14
pubmed:abstractText
The immune system changes dramatically with age. There is a decline in the production of naive lymphocytes by the central lymphoid organs, the thymus and bone marrow. This leads to a reduced diversity and altered repertoire of antigen specificities recognized by the immune system. Thus, with age there is a progressive decline in the capacity of the immune system to react with foreign antigens associated with an increased reactivity with autoantigens. As T cells specific for certain microbial antigens decline with age, their capacity to prevent reactivation of certain chronic infections such as herpes zoster diminishes. This results in the increased reactivation of herpes zoster in persons over 45 years old.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0364-5134
pubmed:author
pubmed:issnType
Print
pubmed:volume
35 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S35-7
pubmed:dateRevised
2005-11-22
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Immune senescence.
pubmed:affiliation
Department of Medicine, Cornell University Medical College, New York, NY 10021-4896.
pubmed:publicationType
Journal Article, Review