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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1994-6-16
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pubmed:abstractText |
The HLA-G monomorphic, nonclassical class I gene encodes the major histocompatibility complex (MHC) molecule, which is the only MHC antigen expressed on cytotrophoblast cells of placenta. In this work, we have investigated expression of the HLA-G gene in fetal tissues and adult peripheral blood cells by using a sensitive hot-start reverse transcriptase PCR technique. PCR amplification with HLA-G primers specific for exon 3 has enabled us to demonstrate an alternatively spliced form of HLA-G mRNA present in fetal first trimester trophoblasts and lacking exon 4 (HLA-G.3-5). This low abundance transcript (approximately 1:200) in comparison to full-length mRNA may encode the protein that excludes the alpha 3 domain and by conformational changes may present a different ability to bind to peptides. Moreover, expression of the HLA-G transcript was found in adult peripheral lymphocytes and equally in B- and T-cell populations. These results are discussed in the context of the fetal-maternal relationship presented by HLA-G gene products.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1544544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1552281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1570318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1624808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1688605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1786078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1908512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-1916822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2016528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2066177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2249951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2257496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2295808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2326636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2336406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2438694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-2841643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-3174659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-3260916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-3480534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8246825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8314554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8340616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8360483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8366871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8370588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8376798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8428749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8449247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8473737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8183892-8481485
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
91
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pubmed:geneSymbol |
HLA-A,
HLA-B,
HLA-C,
HLA-E,
HLA-F,
HLA-G
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4209-13
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8183892-Humans,
pubmed-meshheading:8183892-Pregnancy,
pubmed-meshheading:8183892-Fetus,
pubmed-meshheading:8183892-Lymphocytes,
pubmed-meshheading:8183892-Placenta,
pubmed-meshheading:8183892-Embryo, Mammalian,
pubmed-meshheading:8183892-Female,
pubmed-meshheading:8183892-Adult,
pubmed-meshheading:8183892-Maternal-Fetal Exchange,
pubmed-meshheading:8183892-Base Sequence,
pubmed-meshheading:8183892-Trophoblasts,
pubmed-meshheading:8183892-Gestational Age,
pubmed-meshheading:8183892-Molecular Sequence Data,
pubmed-meshheading:8183892-Pregnancy Trimester, First,
pubmed-meshheading:8183892-T-Lymphocytes,
pubmed-meshheading:8183892-Cloning, Molecular,
pubmed-meshheading:8183892-HLA Antigens,
pubmed-meshheading:8183892-Genes, MHC Class I,
pubmed-meshheading:8183892-Restriction Mapping,
pubmed-meshheading:8183892-DNA, Complementary,
pubmed-meshheading:8183892-Histocompatibility Antigens Class I,
pubmed-meshheading:8183892-Gene Expression,
pubmed-meshheading:8183892-DNA Primers,
pubmed-meshheading:8183892-Alternative Splicing,
pubmed-meshheading:8183892-Polymerase Chain Reaction,
pubmed-meshheading:8183892-HLA-G Antigens
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