|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-6-14
|
|
pubmed:abstractText |
Association of immunoglobulin allotypes with myasthenia gravis was examined in a set of 84 patients presenting autoantibodies against muscle acetylcholine receptor (AChR). Km and G1m(f)/G1m(z) allotypes were determined by PCR-amplification followed by hybridization with allele-specific oligonucleotides. The Km3 kappa light chain allotype was found to be associated with significantly increased serum levels of anti-AChR autoantibodies in myasthenic patients (P = 0.014). We hypothesize that an allelic polymorphism of a regulatory (enhancer) sequence closely linked to the C kappa gene segment could account for our finding.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
221-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8182118-Alleles,
pubmed-meshheading:8182118-Autoantibodies,
pubmed-meshheading:8182118-Humans,
pubmed-meshheading:8182118-Immunoglobulin Allotypes,
pubmed-meshheading:8182118-Immunoglobulin Gm Allotypes,
pubmed-meshheading:8182118-Immunoglobulin kappa-Chains,
pubmed-meshheading:8182118-Muscles,
pubmed-meshheading:8182118-Myasthenia Gravis,
pubmed-meshheading:8182118-Polymerase Chain Reaction,
pubmed-meshheading:8182118-Receptors, Cholinergic
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Association of Km3 allotype with increased serum levels of autoantibodies against muscle acetylcholine receptor in myasthenia gravis.
|
|
pubmed:affiliation |
INSERM U25, Hôpital Necker, Paris, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
