Linked Life Data

8181450

Source:http://linkedlifedata.com/resource/pubmed/id/8181450

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-15
pubmed:abstractText
CTP:cholinephosphate cytidylyltransferase (CT) is a key enzyme required for surfactant phosphatidylcholine synthesis, and its activity is regulated by lung lipids. This study evaluated the effect of epidermal growth factor (EGF) on the phospholipid content and the expression of CT in the lung following direct in vivo administration to the newborn rat. EGF caused an increase in cytidylyltransferase activity by 58% in lung cytosol. The increase in cytosolic activity was not mediated by a corresponding increase in enzyme mass. Further, these changes in cytidylyltransferase activity were associated with a significant increase in total lung phospholipid and phosphatidylcholine content. The results suggest that EGF may have important maturational effects on lung surfactant metabolism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0190-2148
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Epidermal growth factor is a positive in vivo regulator of CTP:cholinephosphate cytidylyltransferase.
pubmed:affiliation
Department of Internal Medicine, Department of Veterans Affairs Medical Center, Iowa City, Iowa.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.