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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-6-16
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pubmed:abstractText |
Forty-six patients with Dupuytren's contracture (DC) and 55 control persons were HLA-typed for class I and HLA-DR class II antigens and were investigated for the presence of autoantibodies against elastin (ELAB) and collagen types I-IV (ACA I-IV). Using the chi 2 test, obtained from 2 x 2 contingency tables, a significant association was found between DC and HLA-DR3 and autoantibodies to types I-IV collagen. ELAB and ACA I and III were significantly correlated with HLA-DR3 in the whole group of patients plus controls. In analogy to other diseases with autoimmunologic features the presence of HLA-DR3 therefore seems to indicate a higher risk for the formation of connective tissue autoantibodies. The remodeling processes during the course of fibrosis in DC might be responsible for this autoantibody formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0090-1229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
142-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8181183-Adult,
pubmed-meshheading:8181183-Aged,
pubmed-meshheading:8181183-Antigens,
pubmed-meshheading:8181183-Autoantibodies,
pubmed-meshheading:8181183-Collagen,
pubmed-meshheading:8181183-Connective Tissue,
pubmed-meshheading:8181183-Dupuytren Contracture,
pubmed-meshheading:8181183-Elastin,
pubmed-meshheading:8181183-Female,
pubmed-meshheading:8181183-Follow-Up Studies,
pubmed-meshheading:8181183-HLA-DR3 Antigen,
pubmed-meshheading:8181183-Histocompatibility Antigens Class I,
pubmed-meshheading:8181183-Histocompatibility Antigens Class II,
pubmed-meshheading:8181183-Humans,
pubmed-meshheading:8181183-Male,
pubmed-meshheading:8181183-Middle Aged,
pubmed-meshheading:8181183-Prevalence,
pubmed-meshheading:8181183-Reference Values
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pubmed:year |
1994
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pubmed:articleTitle |
Prevalence of HLA-DR3 and autoantibodies to connective tissue components in Dupuytren's contracture.
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pubmed:affiliation |
Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna-Oberlaa, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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