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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-6-14
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pubmed:abstractText |
UV irradiation of mammalian cells activates AP-1 through a Ras-dependent pathway, independently of DNA damage. We show that the yeast S. cerevisiae has a remarkably similar UV response involving the AP-1 factor Gcn4, which is distinct from the DNA damage response. Transcriptional activation of HIS3 and HIS4 by Gcn4 is triggered by UV irradiation in a Ras-dependent fashion. Moreover, resistance of yeast to UV irradiation is correlated with the level of Ras activity and Gcn4 function. Like mammalian cells in which activated Ras leads to increased c-Jun synthesis and phosphorylation, the effects in yeast involve increased translation of GCN4 mRNA and a posttranslational event. However, this effect on GCN4 translation is different from the response to amino acid or purine starvation. Therefore, a UV signaling pathway involving Ras and AP-1 is an ancient and universal mechanism involved in protection against damage to cellular components other than DNA.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
381-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8181058-Amitrole,
pubmed-meshheading:8181058-Animals,
pubmed-meshheading:8181058-Base Sequence,
pubmed-meshheading:8181058-DNA Repair,
pubmed-meshheading:8181058-DNA-Binding Proteins,
pubmed-meshheading:8181058-Fungal Proteins,
pubmed-meshheading:8181058-Gene Expression Regulation, Fungal,
pubmed-meshheading:8181058-Genes, Fungal,
pubmed-meshheading:8181058-Genes, ras,
pubmed-meshheading:8181058-Molecular Sequence Data,
pubmed-meshheading:8181058-Protein Biosynthesis,
pubmed-meshheading:8181058-Protein Kinases,
pubmed-meshheading:8181058-Recombinant Fusion Proteins,
pubmed-meshheading:8181058-Saccharomyces cerevisiae,
pubmed-meshheading:8181058-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8181058-Signal Transduction,
pubmed-meshheading:8181058-Transcription, Genetic,
pubmed-meshheading:8181058-Transcription Factors,
pubmed-meshheading:8181058-Ultraviolet Rays
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pubmed:year |
1994
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pubmed:articleTitle |
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093-0636.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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