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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0027627,
umls-concept:C0185117,
umls-concept:C0205281,
umls-concept:C0292863,
umls-concept:C0330390,
umls-concept:C1306673,
umls-concept:C1334087,
umls-concept:C1513095,
umls-concept:C1522492,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1994-6-14
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pubmed:abstractText |
Among a series of adhesion molecules, expression of integrin alpha 4 beta 1 showed a unique inverse correlation with the invasive potential of B16 melanoma cell lines. When an alpha 4 cDNA was introduced into an alpha 4-beta 1+ highly invasive melanoma line, alpha 4 beta 1 heterodimers were expressed on the surface. Matrigel invasion by the alpha 4+ beta 1+ cells was reduced. Pulmonary metastasis was also suppressed when the transfectants were placed subcutaneously, but not when injected intravenously. Expression of alpha 4 beta 1 promoted homotypic intercellular adhesion. The homotypic adhesion was abrogated, and the alpha 4+ beta 1+ (less invasive cell lines) increased matrigel invasion following the anti-alpha 4 MAb treatment. These results suggest that integrin alpha 4 beta 1 could play a role in controlling melanoma cell metastasis at the invasive stage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Very Late Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-47
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8181055-Animals,
pubmed-meshheading:8181055-Antibodies, Monoclonal,
pubmed-meshheading:8181055-Cell Adhesion,
pubmed-meshheading:8181055-Cell Adhesion Molecules,
pubmed-meshheading:8181055-Collagen,
pubmed-meshheading:8181055-DNA, Complementary,
pubmed-meshheading:8181055-Drug Combinations,
pubmed-meshheading:8181055-Genetic Vectors,
pubmed-meshheading:8181055-Integrin alpha4beta1,
pubmed-meshheading:8181055-Integrins,
pubmed-meshheading:8181055-Laminin,
pubmed-meshheading:8181055-Lung Neoplasms,
pubmed-meshheading:8181055-Male,
pubmed-meshheading:8181055-Melanoma, Experimental,
pubmed-meshheading:8181055-Mice,
pubmed-meshheading:8181055-Mice, Inbred C57BL,
pubmed-meshheading:8181055-Neoplasm Invasiveness,
pubmed-meshheading:8181055-Proteoglycans,
pubmed-meshheading:8181055-RNA, Messenger,
pubmed-meshheading:8181055-Receptors, Very Late Antigen,
pubmed-meshheading:8181055-Retroviridae,
pubmed-meshheading:8181055-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation.
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pubmed:affiliation |
Laboratory of Experimental Oncology, Department of Pathology, Stanford University School of Medicine, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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