| pubmed-article:8178966 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8178966 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:8178966 | lifeskim:mentions | umls-concept:C0035322 | lld:lifeskim |
| pubmed-article:8178966 | lifeskim:mentions | umls-concept:C0596156 | lld:lifeskim |
| pubmed-article:8178966 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:8178966 | pubmed:issue | 4 Pt 1 | lld:pubmed |
| pubmed-article:8178966 | pubmed:dateCreated | 1994-6-9 | lld:pubmed |
| pubmed-article:8178966 | pubmed:abstractText | Intracellular pH (pHi) measurements in frog retinal pigment epithelium using the pH-sensitive dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein demonstrate that the basolateral membrane contains a pHi-sensitive Cl-HCO3 exchanger. In control Ringer solution, the removal of Cl from the basal bath alkalinized the cells by 0.07 +/- 0.03 (SD) pH units (n = 39) with an initial rate of 0.022 +/- 0.0013 pH units/min. This effect was blocked by 0.5 mM basal 4,4'-diisothiocyanostilbene-2,2'- disulfonic acid or the removal of HCO3 from both the apical and basal baths. The rate of the exchange is reduced by acidification and increased by alkalinization. Increasing apical bath K concentration ([K]o) from 2 to 5 mM approximates the [K]o change in the subretinal space of the intact eye following a transition from light to dark. This [K]o change alkalinized the cells by increasing the rate of the apical membrane Na-HCO3 cotransporter. In 5 mM apical [K]o, the initial rate of the 0 Cl-induced alkalinization was significantly increased to 304 +/- 13% (n = 4) of control (2 mM [K]o). These mechanisms regulate pHi and could also buffer changes in subretinal pH. | lld:pubmed |
| pubmed-article:8178966 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8178966 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8178966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178966 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8178966 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8178966 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8178966 | pubmed:author | pubmed-author:LipJJ | lld:pubmed |
| pubmed-article:8178966 | pubmed:author | pubmed-author:MillerS SSS | lld:pubmed |
| pubmed-article:8178966 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8178966 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:8178966 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8178966 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8178966 | pubmed:pagination | C935-45 | lld:pubmed |
| pubmed-article:8178966 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8178966 | pubmed:meshHeading | pubmed-meshheading:8178966-... | lld:pubmed |
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| pubmed-article:8178966 | pubmed:meshHeading | pubmed-meshheading:8178966-... | lld:pubmed |
| pubmed-article:8178966 | pubmed:meshHeading | pubmed-meshheading:8178966-... | lld:pubmed |
| pubmed-article:8178966 | pubmed:meshHeading | pubmed-meshheading:8178966-... | lld:pubmed |
| pubmed-article:8178966 | pubmed:meshHeading | pubmed-meshheading:8178966-... | lld:pubmed |
| pubmed-article:8178966 | pubmed:meshHeading | pubmed-meshheading:8178966-... | lld:pubmed |
| pubmed-article:8178966 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8178966 | pubmed:articleTitle | pHi-dependent Cl-HCO3 exchange at the basolateral membrane of frog retinal pigment epithelium. | lld:pubmed |
| pubmed-article:8178966 | pubmed:affiliation | School of Optometry, University of California, Berkeley 94720. | lld:pubmed |
| pubmed-article:8178966 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8178966 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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