| pubmed-article:8178798 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8178798 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8178798 | lifeskim:mentions | umls-concept:C0038454 | lld:lifeskim |
| pubmed-article:8178798 | lifeskim:mentions | umls-concept:C0002895 | lld:lifeskim |
| pubmed-article:8178798 | lifeskim:mentions | umls-concept:C0002312 | lld:lifeskim |
| pubmed-article:8178798 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8178798 | pubmed:dateCreated | 1994-6-3 | lld:pubmed |
| pubmed-article:8178798 | pubmed:abstractText | In an effort to identify possible risk factors for stroke in Sickle Cell Anemia (Hb SS), we analyzed the distribution of alpha-globin gene deletions in a group of Hb SS patients with and without stroke. The group with stroke consisted of 44 patients, (27 male, 17 female) with a mean of 7.5 years at time of stroke. The control group (non-stroke) had 256 Hb SS patients (126 male, 130 female) with a mean age of 7.7 years. There were 9 patients with heterozygous alpha-thalassemia in the stroke group (20.5%). In the control group, there were 93 patients with heterozygous alpha-thalassemia and 5 with homozygous alpha-thalassemia. The incidence of alpha-thalassemia in Hb SS patients without stroke (38%) was comparable to that reported for the African-American population in general. The incidence in the stroke population (20.5%) was significantly lower (P = 0.02) These results indicate that alpha-thalassemia is associated with a lower risk of stroke in Hb SS. This observation should be confirmed in studies involving larger numbers of patients. Possible protective effects of alpha-thalassemia are unknown but may be related to decreased hemolysis and more favorable rheologic properties of red blood cells. | lld:pubmed |
| pubmed-article:8178798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178798 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8178798 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178798 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8178798 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8178798 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8178798 | pubmed:issn | 0361-8609 | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:CarrCC | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:LiuJ CJC | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:AdamsR JRJ | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:KutlarAA | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:ClarkOO | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:NicholsF TFT | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:McKieVV | lld:pubmed |
| pubmed-article:8178798 | pubmed:author | pubmed-author:McKieKK | lld:pubmed |
| pubmed-article:8178798 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8178798 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8178798 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8178798 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8178798 | pubmed:pagination | 279-82 | lld:pubmed |
| pubmed-article:8178798 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8178798 | pubmed:meshHeading | pubmed-meshheading:8178798-... | lld:pubmed |
| pubmed-article:8178798 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8178798 | pubmed:articleTitle | Alpha thalassemia and stroke risk in sickle cell anemia. | lld:pubmed |
| pubmed-article:8178798 | pubmed:affiliation | Department of Neurology, Medical College of Georgia, Augusta 30912. | lld:pubmed |
| pubmed-article:8178798 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8178798 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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