Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-6-6
|
| pubmed:abstractText |
Herpes simplex virus type I (HSV-1) establishes a latent infection in sensory ganglion neurons. During latency no viral-specific proteins are detected and virus gene expression is restricted to the latency-associated transcripts. We report here that trigeminal ganglia of mice with severe combined immunodeficiency contain individual sensory neurons exhibiting restricted viral gene expression characteristic of latency; this occurred during acute (4-6 days) infection with the wild-type HSV-1 strain 17+ and after prolonged (4 weeks) infection with the replication impaired HSV-1 mutant in 1814. These results indicate that T and B lymphocytes, while important for the recovery from viral infections, are not required for the establishment or maintenance of latency in neurons.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0042-6822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
200
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
791-5
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8178461-Animals,
pubmed-meshheading:8178461-Female,
pubmed-meshheading:8178461-Gene Expression,
pubmed-meshheading:8178461-Herpes Simplex,
pubmed-meshheading:8178461-Herpesvirus 1, Human,
pubmed-meshheading:8178461-Immunohistochemistry,
pubmed-meshheading:8178461-In Situ Hybridization,
pubmed-meshheading:8178461-Lymphocytes,
pubmed-meshheading:8178461-Male,
pubmed-meshheading:8178461-Mice,
pubmed-meshheading:8178461-Mice, Inbred BALB C,
pubmed-meshheading:8178461-Mice, SCID,
pubmed-meshheading:8178461-Neurons, Afferent,
pubmed-meshheading:8178461-RNA, Messenger,
pubmed-meshheading:8178461-Severe Combined Immunodeficiency,
pubmed-meshheading:8178461-Time Factors,
pubmed-meshheading:8178461-Trigeminal Ganglion,
pubmed-meshheading:8178461-Virus Latency,
pubmed-meshheading:8178461-Virus Replication
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Restricted herpes simplex virus type 1 gene expression within sensory neurons in the absence of functional B and T lymphocytes.
|
| pubmed:affiliation |
Wistar Institute, Philadelphia, Pennsylvania 19104.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|