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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1994-6-9
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pubmed:abstractText |
The renin-angiotensin system is a powerful pressor system with a major influence on salt and water homeostasis. Angiotensinogen (also called renin substrate) is a key component of this system; it is cleaved by renin to yield angiotensin I, which is then cleaved by angiotensin-converting enzyme to yield angiotensin II. The observation that plasma angiotensinogen levels correlate with blood pressure and track through families suggests that angiotensinogen may have a role in essential hypertension. We therefore investigated whether there is linkage between the angiotensinogen gene on chromosome 1q42-43 and essential hypertension.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
330
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1629-33
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8177268-Aged,
pubmed-meshheading:8177268-Angiotensinogen,
pubmed-meshheading:8177268-Base Sequence,
pubmed-meshheading:8177268-Chromosomes, Human, Pair 1,
pubmed-meshheading:8177268-DNA Primers,
pubmed-meshheading:8177268-Exons,
pubmed-meshheading:8177268-Female,
pubmed-meshheading:8177268-Genetic Linkage,
pubmed-meshheading:8177268-Humans,
pubmed-meshheading:8177268-Hypertension,
pubmed-meshheading:8177268-Male,
pubmed-meshheading:8177268-Methionine,
pubmed-meshheading:8177268-Middle Aged,
pubmed-meshheading:8177268-Molecular Sequence Data,
pubmed-meshheading:8177268-Polymerase Chain Reaction,
pubmed-meshheading:8177268-Polymorphism, Genetic,
pubmed-meshheading:8177268-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8177268-Threonine
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pubmed:year |
1994
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pubmed:articleTitle |
Linkage of the angiotensinogen gene to essential hypertension.
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pubmed:affiliation |
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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