Linked Life Data

8174801

Source:http://linkedlifedata.com/resource/pubmed/id/8174801

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-6-9
pubmed:abstractText
Photodynamic virus inactivation of human fresh plasma is achieved by illuminating single units of plasma in their plastic containers with light from fluorescent tubes in the presence of the phenothiazine dye methylene blue. The effective dye concentration is 1 microM, i.e. approx. 300 micrograms per litre of plasma. Under the conditions used, all enveloped viruses tested so far have been sensitive to photodynamic treatment, although some had to be illuminated for a longer time than others. For example, under production conditions the infectivity of SFV-containing plasma was reduced by more than 7 log10 within five minutes, whereas 30 minutes were required to reduce the infectivity of plasma containing VSV by c. 5 log10. Among the non-enveloped viruses tested some were sensitive to photodynamic treatment (e.g. SV40 and calicivirus) and some were not (e.g. encephalomyocarditis and polioviruses). Using the optimized procedure, plasma proteins remain largely unaffected. Photodynamically treated fresh frozen plasma (FFP) has been routinely produced and distributed since February 1992. Requested reporting of adverse drug reactions indicates that the virus inactivated product is a well tolerated as conventional FFP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-83
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Photo-inactivation of viruses in therapeutical plasma.
pubmed:affiliation
German Red Cross Blood Transfusion Service Lower Saxony, Institute Springe.
pubmed:publicationType
Journal Article, Comparative Study