Linked Life Data

8174776

Source:http://linkedlifedata.com/resource/pubmed/id/8174776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-9
pubmed:abstractText
The Drosophila melanogaster fs (1) Ya gene encodes a nuclear envelope protein needed to initiate embryonic cleavage divisions. In cleavage stage embryos the fs (1) Ya gene product is localized to the nuclear envelope in a cell cycle dependent manner. We show here that fs(1)Ya protein is also present in polar bodies of early cleavage stage embryos as well as in endoreplicating yolk nuclei. This observation suggests that the fs(1)Ya protein is necessary but not solely responsible for embryonic mitosis. Furthermore, cell cycle stage dependent nuclear localization is also seen for ectopically produced fs(1)Ya protein in tissue culture cells, neuroblasts, and male accessory glands, which are free of maternal products. We therefore conclude that cell cycle dependent nuclear localization does not require any exclusively maternal products. Finally, our immunoelectron microscopy shows that the fs(1)Ya protein distribution parallels that of lamin, indicating that it is a nuclear lamina protein.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
202-11
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei.
pubmed:affiliation
Section of Genetics and Development, Cornell University, Ithaca, New York 14853-2703.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't