Linked Life Data

8174773

Source:http://linkedlifedata.com/resource/pubmed/id/8174773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-9
pubmed:abstractText
ATBF1 is a transcription factor containing four homeodomains and 17 zinc fingers. Since the Drosophila homolog, ZFH-2, is implicated in neurogenesis, we examined ATBF1 expression in developing mouse brain and in P19 mouse embryonal carcinoma cells during differentiation. We found that pre- and postnatal mouse brains expressed high levels of ATBF1 mRNA, but the adult brain contained only a small amount of ATBF1 transcripts. In P19 cells, ATBF1 transcripts were undetectable before differentiation; however, 1 day after induction of neuronal differentiation with retinoic acid, ATBF1 mRNA was expressed at a high level. This increased level reached a maximum on the 4th day and then declined. No comparable level of ATBF1 mRNA was expressed when P19 cells were treated with dimethyl sulfoxide to induce muscle cells. These temporal patterns of ATBF1 expression in vivo and in vitro suggest that ATBF1 may play a role in neuronal differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
184-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells.
pubmed:affiliation
Department of Medical Biochemistry, University of Calgary, Alberta, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't