Linked Life Data

8174506

Source:http://linkedlifedata.com/resource/pubmed/id/8174506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-8
pubmed:abstractText
Previous experiments have shown that chronic ethanol consumption in mice for 12 months produced memory deficits associated with both alterations in diencephalic structures (ie, cellular loss, hypometabolism, particularly in mamillary bodies) and with hippocampal and cortical cholinergic hypofunction (Béracochéa et al., Pharmacol Biochem Behav 1992; 42: 749-53). The present study was aimed at comparing the effects of tianeptine and paroxetine (10 mg.kg-1, i.p.), that have opposite properties on serotoninergic transmission, on this alcohol-induced memory deficits. For this purpose, animals were submitted to a T-maze sequential alternation task in which they were given daily series of 6 successive trials separated by a 30-second interval. Behavioural testing began following a 4-week complete withdrawal period. The experiment was conducted in two steps. In the first part, animals received no treatment. Results showed that, as compared to the control group (pair-fed, n = 7), alcohol-treated mice (n = 20) displayed a trial-specific impairment of alternation rates. Specifically, they were impaired on the last three trials (4-6) of the series (52.2 vs 81.0%, p < 0.001), but performed normally on the first ones (2-3), suggesting thereby an increased sensitivity to proactive interference (Béracochéa et al., Behav Brain Res 1987; 25: 63-74). In the second part of the experiment the alcohol group was divided into three homogeneous groups according to the treatment they received 30 minutes before each daily session (ie, placebo, tianeptine, paroxetine).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0013-7006
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Comparison of the effects of tianeptine and paroxetine on amnesic deficits induced by prolonged alcohol drinking in mice].
pubmed:affiliation
Laboratoire de Neurosciences Comportementales et Cognitives, CNRS URA 339, Université de Bordeaux I, Talence.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract