Linked Life Data

8173970

Source:http://linkedlifedata.com/resource/pubmed/id/8173970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-6-9
pubmed:abstractText
We have attempted to identify some novel genes which were found to be more highly expressed in the embryonic brain than in the adult brain. Consequently, one of these clones was identified as alpha-globin cDNA. Actually, alpha-globin mRNA was detected in the neurons. In addition, beta-globin mRNA was detected in the neurons as well. Both globin mRNAs were developmentally regulated in the same pattern. Subsequently, further examinations with antiserum to hemoglobin revealed the presence of hemoglobin in the neurons. Hemoglobin has, up to now, been known to be an important O2 transporter protein in erythrocytes. Moreover, hemoglobin is now considered to be also a very dangerous protein generating the toxic hydroxyl radical (.OH). We herein show the presence of hemoglobin and its regulation in the central nervous system, which may indicate the presence of a useful function regulating O2 homeostasis and a potential oxidative toxicity for neuronal cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
635
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Hemoglobin as a novel protein developmentally regulated in neurons.
pubmed:affiliation
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't