Linked Life Data

8173343

Source:http://linkedlifedata.com/resource/pubmed/id/8173343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-6-6
pubmed:abstractText
These studies were conducted to assess alterations in renal tubule cell gene expression following in vivo exposure to the semiconductor elements indium (In), arsenic (As) or indium arsenide (InAs). Alterations in proximal tubule cell gene expression were monitored at similar tissue concentrations of In or As at various time-points following single subcutaneous (sc) injections of In, As or InAs at 0, 10 and 30 days (In: 1.5 mg/kg; As, 3 mg/kg or 0.3 mg/k; and InAs: 1000 mg/kg). Protein synthesis as monitored by incorporation of 35S methionine was not statistically increased over the 30-day period following sc injection of As, In or InAs relative to controls. Two dimensional--SDS/polyacrylamide gel electrophoresis showed that exposure to InAs stimulated the synthesis of a number of proteins with molecular masses of < 10, 18, 28, 32, 38, 42, 58, 70, 98 KDa. Exposure to As produced an increase in the expression of thirteen gene products. Indium produced similar changes at the 10-day time-point, but increased tissue accumulation of this element at 30 days markedly suppressed the stress protein response. These data indicate that induction of these specific gene expression patterns may be useful as early indicators for assessing exposure to InAs, or inorganic As, while suppression of these responses by In suggests a compromise in this basic protective mechanism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1053-4245
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Biological indicators for monitoring exposure/toxicity from III-V semiconductors.
pubmed:affiliation
University of Maryland, Graduate School Baltimore 21227.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.