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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1994-6-1
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pubmed:abstractText |
Non-insulin-dependent diabetes mellitus (NIDDM) is considered a model of premature atherosclerosis with a strong genetic component. We have investigated the role of angiotensin-converting enzyme (ACE; EC 3.4.15.1) gene in 316 unrelated NIDDM individuals, 132 who had myocardial infarction or significant coronary stenoses and 184 with no history of coronary heart disease (CHD). A deletion-polymorphism in the ACE gene was recently reported to be associated with myocardial infarction especially in people classified as low risk. Here we report that the D allele of the ACE gene is a strong and independent risk factor for CHD in NIDDM patients. The D allele is associated with early-onset CHD in NIDDM, independently of hypertension and lipid values. A progressively increasing relative risk in individuals heterozygous and homozygous for the D allele was observed (odds ratios of 1.41 and 2.35, respectively; P < 0.007), suggesting a codominant effect on the cardiovascular risk. The percentage of CHD attributable to the ACE deletion allele was 24% in this NIDDM population. Identification of NIDDM patients carrying this putative CHD-susceptibility genotype would help early detection and treatment of CHD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1313972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1328889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1331171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1359258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1386652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1409481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1417827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1580275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1729850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1736105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1955104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-1976655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-2568956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-3056758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-8096947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-8105309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-8432214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8170965-8504511
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3662-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8170965-Alleles,
pubmed-meshheading:8170965-Coronary Disease,
pubmed-meshheading:8170965-Diabetes Mellitus, Type 2,
pubmed-meshheading:8170965-Female,
pubmed-meshheading:8170965-Gene Deletion,
pubmed-meshheading:8170965-Gene Frequency,
pubmed-meshheading:8170965-Humans,
pubmed-meshheading:8170965-Male,
pubmed-meshheading:8170965-Middle Aged,
pubmed-meshheading:8170965-Peptidyl-Dipeptidase A,
pubmed-meshheading:8170965-Regression Analysis,
pubmed-meshheading:8170965-Risk Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.
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pubmed:affiliation |
Centre d'Etude du Polymorphisme Humain, (Fondation Jean Dausset-CEPH), Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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