Linked Life Data

8168129

Source:http://linkedlifedata.com/resource/pubmed/id/8168129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-6-1
pubmed:abstractText
The sigma F factor establishes cell type-specific gene transcription during sporulation in B. subtilis. sigma F is negatively regulated by SpollAB, which forms complexes with sigma F or SpollAA. ATP and its nonhydrolyzable analogs stimulate the formation of the SpollAB.sigma F complex, whereas ADP stimulates the formation of the SpollAB.SpollAA complex. Which protein SpollAB associates with is determined by the concentrations of the two nucleotides, on which basis we propose a partner-switching model for the regulation of sigma F: [formula: see text] Consistent with this model, SpollAA reverses SpollAB-mediated inhibition of sigma F-directed transcription in a manner that depends on ADP. Cell-specific activation of sigma F could be due to an alteration in adenosine nucleotide levels in one cell of the sporangium.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-205
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis.
pubmed:affiliation
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't