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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-6-1
|
| pubmed:abstractText |
In sera from 476 diabetic outpatients, positive reaction in the Fluorescent Treponemal Antibody-Absorption (FTA-Abs) test, a commonly used serological test for syphilis, was found in 36 of the patients. None of 100 healthy control subjects were positive in the FTA-Abs test. Additional treponemal and nontreponemal tests confirmed the diagnosis of syphilis in only three of the diabetic patients. In 10 of the 36 patients, the positive FTA-Abs reactivity appeared to be due to cross-reactivity between the treponemal antigen and Borrelia burgdorferi, which causes Lyme borreliosis. In the remaining 23 patients (5%), no other explanation for a false-positive FTA-Abs reactivity was found besides diabetes. Diabetic patients with false-positive FTA-Abs reactivity had similar degree of long-term metabolic control and prevalence of islet cell antibodies (ICA) as well as late diabetic complications as FTA-Abs negative diabetic patients, matched regarding to sex, age, type, and duration of diabetes. In conclusion, false-positive FTA-Abs reactivity is not rare in diabetic patients. The reason for this phenomenon is unknown, but could be a sign of autoimmunity of its own. Hence, in diabetic patients with FTA-Abs test indicating syphilis, the diagnosis must be verified with a combination of other tests.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1056-8727
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
57-62
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8167389-Adolescent,
pubmed-meshheading:8167389-Adult,
pubmed-meshheading:8167389-Aged,
pubmed-meshheading:8167389-Blood Donors,
pubmed-meshheading:8167389-Child,
pubmed-meshheading:8167389-Child, Preschool,
pubmed-meshheading:8167389-Cross Reactions,
pubmed-meshheading:8167389-Diabetes Mellitus,
pubmed-meshheading:8167389-Diabetic Nephropathies,
pubmed-meshheading:8167389-Diabetic Neuropathies,
pubmed-meshheading:8167389-Diabetic Retinopathy,
pubmed-meshheading:8167389-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8167389-False Positive Reactions,
pubmed-meshheading:8167389-Female,
pubmed-meshheading:8167389-Fluorescent Treponemal Antibody-Absorption Test,
pubmed-meshheading:8167389-Humans,
pubmed-meshheading:8167389-Lyme Disease,
pubmed-meshheading:8167389-Male,
pubmed-meshheading:8167389-Middle Aged,
pubmed-meshheading:8167389-Reference Values,
pubmed-meshheading:8167389-Sex Factors,
pubmed-meshheading:8167389-Syphilis Serodiagnosis
|
| pubmed:articleTitle |
False-positive treponemal serology in patients with diabetes mellitus.
|
| pubmed:affiliation |
Department of Clinical Bacteriology, Stockholm County Council Central Microbiological Laboratory, Sweden.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|