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pubmed:abstractText |
The proteins encoded by the VpreB and lambda 5 genes associate with each other to form a light (L) chain-like structure, the surrogate L chain. It can form Ig-like complexes with three partners-the classical heavy (H) chain, the DHJHC mu-protein, or the newly discovered p55 chain; these are expressed on the surface of pre-B cells at different stages of development. Here, Fritz Melchers and colleagues review the structures of the VpreB and lambda 5 genes in mouse and their relatives in humans, describe their pattern of expression, and speculate on their possible evolution and functions.
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pubmed:geneSymbol |
&lgr;5,
D<down>H</down>,
G&lgr;1,
J&lgr;L,
J<down>H</down>,
J<down>L</down>,
RAG-2,
V&lgr;L,
V<down>H</down>,
V<down>L</down>,
V<down>preB1</down>,
V<down>preB</down>
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