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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 mug TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, whereas N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
227-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:816658-Animals,
pubmed-meshheading:816658-Behavior, Animal,
pubmed-meshheading:816658-Injections, Intraventricular,
pubmed-meshheading:816658-Male,
pubmed-meshheading:816658-Motor Activity,
pubmed-meshheading:816658-Rats,
pubmed-meshheading:816658-Structure-Activity Relationship,
pubmed-meshheading:816658-Thyrotropin-Releasing Hormone
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pubmed:year |
1976
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pubmed:articleTitle |
Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat.
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pubmed:publicationType |
Journal Article,
Comparative Study
|