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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
1994-5-25
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|
pubmed:abstractText |
We report here a case of PML in the course of untreated chronic lymphocytic leukaemia. The diagnosis of PML was based on the presence of typical histologic findings in the white matter: focal demyelination, abnormal oligodendroglia with basophilic intranuclear inclusions and enlarged bizarre astrocytes. It was confirmed by immunohistochemistry which revealed JC papova-virus antigens in brain tissue and by in-situ hybridization which showed JC virus genomic DNA in oligodendroglial nuclei. Virus particles in the nuclei of abnormal oligodendrocytes and astrocytes were demonstrated by thin-section electron-microscopy.
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pubmed:language |
pol
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0028-3843
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
905-12
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|
pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8164786-Aged,
pubmed-meshheading:8164786-Astrocytes,
pubmed-meshheading:8164786-Brain,
pubmed-meshheading:8164786-DNA, Viral,
pubmed-meshheading:8164786-Demyelinating Diseases,
pubmed-meshheading:8164786-Female,
pubmed-meshheading:8164786-Humans,
pubmed-meshheading:8164786-Immunohistochemistry,
pubmed-meshheading:8164786-In Situ Hybridization,
pubmed-meshheading:8164786-JC Virus,
pubmed-meshheading:8164786-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:8164786-Leukoencephalopathy, Progressive Multifocal,
pubmed-meshheading:8164786-Microscopy, Electron,
pubmed-meshheading:8164786-Oligodendroglia,
pubmed-meshheading:8164786-Papillomaviridae,
pubmed-meshheading:8164786-Polyomaviridae,
pubmed-meshheading:8164786-Tomography, X-Ray Computed
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|
pubmed:articleTitle |
[A case of progressive multifocal leucoencephalopathy during chronic lymphocytic leukaemia].
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|
pubmed:affiliation |
Kliniki Neurologicznej II Wydz. Lek. AM, Warszawie.
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pubmed:publicationType |
Journal Article,
English Abstract,
Case Reports
|
