| pubmed-article:816470 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0596698 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C1947986 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:816470 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:816470 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:816470 | pubmed:dateCreated | 1976-7-6 | lld:pubmed |
| pubmed-article:816470 | pubmed:abstractText | Heterokaryons formed between human myeloma cells and various types of mouse and human non-lymphoid cells loose their cytoplasmic content of lambda light chains, a component of IgE produced by the myeloma parent. This loss of immunoglobulin content was observed regardless of the species origin (mouse or human) of the non-lymphoid partner cell, suggesting that the factors responsible for extinction of this differentiated function are not specific for a species. The kinetics of the loss of immunoglobulin content was essentially identical in the different experiments, since all myeloma X non-lymphoid cell heterokaryons were scored as negative after immunofluorescence staining for lambda chains 4-6 hr after infusion. Myeloma cells treated with inhibitors of protein synthesis (puromycin and cycloheximide) also lost their cytoplasmic content of immunoglobulin after 4 hr. These results indicate that the fusion of myeloma cells with non-lymphoid cells results in an immediate inhibition of immunoglobulin synthesis. | lld:pubmed |
| pubmed-article:816470 | pubmed:language | eng | lld:pubmed |
| pubmed-article:816470 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816470 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:816470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816470 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:816470 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:816470 | pubmed:issn | 0045-6039 | lld:pubmed |
| pubmed-article:816470 | pubmed:author | pubmed-author:NilssonKK | lld:pubmed |
| pubmed-article:816470 | pubmed:author | pubmed-author:ZeuthenJJ | lld:pubmed |
| pubmed-article:816470 | pubmed:author | pubmed-author:StenmanSS | lld:pubmed |
| pubmed-article:816470 | pubmed:author | pubmed-author:FabriciusH... | lld:pubmed |
| pubmed-article:816470 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:816470 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:816470 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:816470 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:816470 | pubmed:pagination | 369-83 | lld:pubmed |
| pubmed-article:816470 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:816470 | pubmed:meshHeading | pubmed-meshheading:816470-H... | lld:pubmed |
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| pubmed-article:816470 | pubmed:meshHeading | pubmed-meshheading:816470-I... | lld:pubmed |
| pubmed-article:816470 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:816470 | pubmed:articleTitle | Expression of immunoglobulin synthesis in human myeloma x non-lymphoid cell heterokaryons: evidence for negative control. | lld:pubmed |
| pubmed-article:816470 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:816470 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:816470 | lld:pubmed |
