Linked Life Data

816470

Source:http://linkedlifedata.com/resource/pubmed/id/816470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1976-7-6
pubmed:abstractText
Heterokaryons formed between human myeloma cells and various types of mouse and human non-lymphoid cells loose their cytoplasmic content of lambda light chains, a component of IgE produced by the myeloma parent. This loss of immunoglobulin content was observed regardless of the species origin (mouse or human) of the non-lymphoid partner cell, suggesting that the factors responsible for extinction of this differentiated function are not specific for a species. The kinetics of the loss of immunoglobulin content was essentially identical in the different experiments, since all myeloma X non-lymphoid cell heterokaryons were scored as negative after immunofluorescence staining for lambda chains 4-6 hr after infusion. Myeloma cells treated with inhibitors of protein synthesis (puromycin and cycloheximide) also lost their cytoplasmic content of immunoglobulin after 4 hr. These results indicate that the fusion of myeloma cells with non-lymphoid cells results in an immediate inhibition of immunoglobulin synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0045-6039
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-83
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Expression of immunoglobulin synthesis in human myeloma x non-lymphoid cell heterokaryons: evidence for negative control.
pubmed:publicationType
Journal Article