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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-5-24
|
| pubmed:abstractText |
In Taiwan, there are two million people who have a betel quid chewing habit, and approximately 80% of all oral cancer deaths are associated with this habit. To investigate the incidence and types of Ki-ras codon 12 mutations in oral cancer associated with betel quid chewing, we used a sensitive mutation-specific two-stage polymerase chain reaction (PCR) technique to examine human oral squamous cell carcinomas from formalin-fixed, paraffin-embedded tissues. DNA sequence analysis of PCR products revealed that 6 of 33 (18%) tumour specimens contained Ki-ras codon 12 mutations. Four of the tumours contained more than one mutation. Three different base changes were detected, resulting from a substitution of wild type glycine (GGT) to either serine (AGT), aspartic acid (GAT) or cysteine (TAT). These results indicate that Ki-ras oncogene activation may play a role in the oncogenesis of betel quid chewing-related human oral squamous cell carcinomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0904-2512
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:geneSymbol |
K-ras,
Ki-ras
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
70-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8164156-Adult,
pubmed-meshheading:8164156-Areca,
pubmed-meshheading:8164156-Base Sequence,
pubmed-meshheading:8164156-Carcinoma, Squamous Cell,
pubmed-meshheading:8164156-Codon,
pubmed-meshheading:8164156-DNA, Neoplasm,
pubmed-meshheading:8164156-DNA Mutational Analysis,
pubmed-meshheading:8164156-Genes, ras,
pubmed-meshheading:8164156-Humans,
pubmed-meshheading:8164156-Male,
pubmed-meshheading:8164156-Middle Aged,
pubmed-meshheading:8164156-Molecular Sequence Data,
pubmed-meshheading:8164156-Mouth Mucosa,
pubmed-meshheading:8164156-Mouth Neoplasms,
pubmed-meshheading:8164156-Mutation,
pubmed-meshheading:8164156-Plants, Medicinal,
pubmed-meshheading:8164156-Polymerase Chain Reaction,
pubmed-meshheading:8164156-Substance-Related Disorders
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan.
|
| pubmed:affiliation |
School of Dentistry, National Taiwan University, Taipei, ROC.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|