| pubmed-article:8163929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8163929 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:8163929 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8163929 | lifeskim:mentions | umls-concept:C1519146 | lld:lifeskim |
| pubmed-article:8163929 | lifeskim:mentions | umls-concept:C1519165 | lld:lifeskim |
| pubmed-article:8163929 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:8163929 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8163929 | pubmed:dateCreated | 1994-5-24 | lld:pubmed |
| pubmed-article:8163929 | pubmed:abstractText | During the study of autoimmune models we found that (SWR x SJL)F1 mice (both parental strains with the V beta a phenotype) spontaneously produced immunoglobulin G (IgG) antibodies directed against Sm/U1 small nuclear ribonucleoproteins (snRNPs). In some of these females, the presence of these autoantibodies was found as early as 10 wk of age. Their frequency increased with age i.e., 70% at 40 wk. At that time, only 10% of males developed anti-Sm/U1snRNP antibodies. Anti-Sm/U1snRNP antibodies from positive mice generally recognized the peptides BB', D, 70 kD, and A from RNPs. These polypeptides are known to bear the autoantigenic epitopes that are recognized by human sera containing anti-Sm and anti-U1snRNP antibodies. Reactivity of IgG antibodies with the octapeptide sequence PPPGMRPP was also found in 30% of anti-Sm/U1snRNP positive (SWR x SJL)F1 mice that precipitated BB' peptides. This octapeptide has been described as the most immunoreactive linear epitope in systemic lupus erythematosus (SLE) patients with anti-Sm and anti-U1snRNP antibodies. Approximately 30% of anti-Sn/U1snRNP positive females, later produced anti-dsDNA antibodies. This fact was accompanied by the development of proteinuria due to glomerulonephritis mediated by immunocomplexes. In addition to the specific autoimmune response, (SWR x SJL)F1 females also showed other immunologic abnormalities such as hypergammaglobulinemia, and an approximately twofold increase in spleen cell number compared with control mice. These results indicate that (SWR x SJL)F1 females develop clinical and serological abnormalities similar to those observed in human SLE and constitute a novel model for the study of the genetic mechanisms that result in autoimmunity. | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8163929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8163929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8163929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8163929 | pubmed:month | May | lld:pubmed |
| pubmed-article:8163929 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8163929 | pubmed:author | pubmed-author:VidalSS | lld:pubmed |
| pubmed-article:8163929 | pubmed:author | pubmed-author:GelpíCC | lld:pubmed |
| pubmed-article:8163929 | pubmed:author | pubmed-author:Rodríguez-Sán... | lld:pubmed |
| pubmed-article:8163929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8163929 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8163929 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:8163929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8163929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8163929 | pubmed:pagination | 1429-35 | lld:pubmed |
| pubmed-article:8163929 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:meshHeading | pubmed-meshheading:8163929-... | lld:pubmed |
| pubmed-article:8163929 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8163929 | pubmed:articleTitle | (SWR x SJL)F1 mice: a new model of lupus-like disease. | lld:pubmed |
| pubmed-article:8163929 | pubmed:affiliation | Department of Immunology, Hospital de Sant Pau, Universitat Autónoma de Barcelona, Spain. | lld:pubmed |
| pubmed-article:8163929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8163929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8163929 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8163929 | lld:pubmed |
