Linked Life Data

8163929

Source:http://linkedlifedata.com/resource/pubmed/id/8163929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-5-24
pubmed:abstractText
During the study of autoimmune models we found that (SWR x SJL)F1 mice (both parental strains with the V beta a phenotype) spontaneously produced immunoglobulin G (IgG) antibodies directed against Sm/U1 small nuclear ribonucleoproteins (snRNPs). In some of these females, the presence of these autoantibodies was found as early as 10 wk of age. Their frequency increased with age i.e., 70% at 40 wk. At that time, only 10% of males developed anti-Sm/U1snRNP antibodies. Anti-Sm/U1snRNP antibodies from positive mice generally recognized the peptides BB', D, 70 kD, and A from RNPs. These polypeptides are known to bear the autoantigenic epitopes that are recognized by human sera containing anti-Sm and anti-U1snRNP antibodies. Reactivity of IgG antibodies with the octapeptide sequence PPPGMRPP was also found in 30% of anti-Sm/U1snRNP positive (SWR x SJL)F1 mice that precipitated BB' peptides. This octapeptide has been described as the most immunoreactive linear epitope in systemic lupus erythematosus (SLE) patients with anti-Sm and anti-U1snRNP antibodies. Approximately 30% of anti-Sn/U1snRNP positive females, later produced anti-dsDNA antibodies. This fact was accompanied by the development of proteinuria due to glomerulonephritis mediated by immunocomplexes. In addition to the specific autoimmune response, (SWR x SJL)F1 females also showed other immunologic abnormalities such as hypergammaglobulinemia, and an approximately twofold increase in spleen cell number compared with control mice. These results indicate that (SWR x SJL)F1 females develop clinical and serological abnormalities similar to those observed in human SLE and constitute a novel model for the study of the genetic mechanisms that result in autoimmunity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-1372022, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-2143968, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-2523951, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-2947846, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-2950197, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-304883, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-309911, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-3372998, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-3491155, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-3890479, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-4142417, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-6753854, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-7104052, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-7678276, http://linkedlifedata.com/resource/pubmed/commentcorrection/8163929-8447933
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1429-35
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
(SWR x SJL)F1 mice: a new model of lupus-like disease.
pubmed:affiliation
Department of Immunology, Hospital de Sant Pau, Universitat Autónoma de Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't