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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-5-24
|
| pubmed:abstractText |
We examined the interrelationship of lipid and glucose metabolism in the basal state and during insulin stimulus in 19 healthy men (27 +/- 2 years, body mass index 23.6 +/- 0.6 kg/m2). In each subject, we performed a 4-h euglycaemic (5.3 +/- 0.1 mmol/l) hyperinsulinaemic (647 +/- 21 pmol/l) insulin clamp with indirect calorimetry in the basal state and during insulin infusion, and muscle biopsies before and at the end of the clamp. In the basal state, serum non-esterified fatty acid levels correlated directly with lipid oxidation (r = 0.56, p < 0.05) and indirectly with glucose oxidation (r = -0.80, p < 0.001). Lipid and glucose oxidation rates were inversely related in the basal state (r = -0.47, p < 0.05) and during insulin infusion (r = -0.65, p < 0.01). Basal lipid oxidation and glycogen synthase total activity correlated inversely (r = -0.54, p < 0.05). Lipid oxidation both in the basal state (r = -0.61, p < 0.01) and during insulin infusion (r = -0.62, p < 0.05) was inversely related to muscle glycogen content after the insulin clamp. Fasting plasma triglyceride concentration correlated directly to fasting insulin (r = 0.55, p < 0.05) and C-peptide (r = 0.50, p < 0.03) concentrations and inversely to non-oxidative glucose disposal rate at the end of clamp (r = -0.54, p < 0.05). In conclusion: 1) Serum non-esterified fatty acid concentration enhances lipid and reduces glucose oxidation. 2) Lipid oxidation is inversely related to total glycogen synthase activity.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
202-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8163056-Adult,
pubmed-meshheading:8163056-Biopsy,
pubmed-meshheading:8163056-Blood Glucose,
pubmed-meshheading:8163056-Calorimetry,
pubmed-meshheading:8163056-Exercise Test,
pubmed-meshheading:8163056-Fatty Acids, Nonesterified,
pubmed-meshheading:8163056-Glucose,
pubmed-meshheading:8163056-Glucose Clamp Technique,
pubmed-meshheading:8163056-Glycogen,
pubmed-meshheading:8163056-Glycogen Synthase,
pubmed-meshheading:8163056-Glycolysis,
pubmed-meshheading:8163056-Humans,
pubmed-meshheading:8163056-Infusions, Intravenous,
pubmed-meshheading:8163056-Insulin,
pubmed-meshheading:8163056-Kinetics,
pubmed-meshheading:8163056-Male,
pubmed-meshheading:8163056-Muscles,
pubmed-meshheading:8163056-Oxygen Consumption,
pubmed-meshheading:8163056-Physical Exertion,
pubmed-meshheading:8163056-Reference Values,
pubmed-meshheading:8163056-Time Factors,
pubmed-meshheading:8163056-Triglycerides
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Non-esterified fatty acids regulate lipid and glucose oxidation and glycogen synthesis in healthy man.
|
| pubmed:affiliation |
Second Department of Medicine, Helsinki University Hospital, Finland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|