Linked Life Data

8162955

Source:http://linkedlifedata.com/resource/pubmed/id/8162955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-5-20
pubmed:abstractText
In rabbit isolated renal artery preparations angiotensin II (1-100 nM) induced concentration-dependent vasoconstriction. Losartan at lower concentrations (3-100 nM) concentration dependently depressed the maximal responses to angiotensin II. At higher concentrations (0.3 and 1 microM) lasartan only shifted the concentration-response curves for angiotensin II to the right without further reducing the maximal responses. PD123177 (1 microM) did not influence angiotensin II-induced contractions. In rabbit renal artery, AT1 but not AT2 receptors appear to mediate the responses to angiotensin II. However, losartan antagonized the AT1 receptors in both an insurmountable and a surmountable manner, possibly involving two subpopulations of AT1 receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-40
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
A non-competitive type of angiotensin-receptor antagonism by losartan in renal artery preparations.
pubmed:affiliation
Department of Pharmacotherapy, University of Amsterdam, Netherlands.
pubmed:publicationType
Journal Article, In Vitro