Linked Life Data

8159818

Source:http://linkedlifedata.com/resource/pubmed/id/8159818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-5-13
pubmed:abstractText
In 1969 Innes et al. reported that 9% of 127 industrial chemicals and pesticides (including 7 positive controls) tested in a mouse bioassay were carcinogenic by oral administration. This is much lower than the prevalence of approximately 50% that has been found recently by the cancer bioassays conducted under the aegis of the U.S. National Toxicology Program (NTP) or reported in Carcinogen Potency Data Base compiled by Gold and collaborators. Using the CASE structure-activity relational expert system and the NTP cancer bioassay results as a learning set, we found that the predicted prevalence of carcinogens among the chemicals tested by Innes et al. is 62.7%. It is concluded that the bioassay protocol used by Innes et al. is less sensitive than the subsequently adopted bioassay procedures.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0273-2300
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-105
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
A reexamination of the low prevalence of carcinogens in an early carcinogen screen.
pubmed:affiliation
International Agency for Research on Cancer, Lyon, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.