Linked Life Data

8159257

Source:http://linkedlifedata.com/resource/pubmed/id/8159257

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-5-13
pubmed:abstractText
The objective of this study was to compare the adenylyl cyclase-cAMP second messenger system in cerebral microvessels isolated from Alzheimer's patients to that in microvessels from nondemented elderly controls. To evaluate the role of aging separate from the effects of dementia, microvessels from young and aged rodents were also examined. The results of this study indicated that microvessels isolated from autopsy material can be used to evaluate adenylyl cyclase activity. The data showed that cAMP levels, as an index of adenylyl cyclase activity, are significantly (p < 0.02) elevated in microvessels from Alzheimer's disease compared to nondemented elderly controls. Stimulation of adenylyl cyclase by forskolin was comparable in both groups of microvessels. A comparison of unstimulated microvessels from young and aged rodents yielded no significant difference in cAMP levels. These results indicate an increased level of cAMP in the microvessels of Alzheimer's patients with no age-related change demonstrable in rat microvessels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Increased accumulation of cAMP in cerebral microvessels in Alzheimer's disease.
pubmed:affiliation
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't