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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0021359,
umls-concept:C0023690,
umls-concept:C0025266,
umls-concept:C0033105,
umls-concept:C0037868,
umls-concept:C0042341,
umls-concept:C0441889,
umls-concept:C0871261,
umls-concept:C1145667,
umls-concept:C1167622,
umls-concept:C1280500,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349209,
umls-concept:C2756969,
umls-concept:C2825311,
umls-concept:C2911692
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-5-19
|
| pubmed:abstractText |
An increased level of antisperm antibodies has been demonstrated in infertile men with varicocele compared with normal fertile men, suggesting a possible cause and effect relationship. To evaluate the possible etiological role of antisperm antibodies in varicocele patients, we performed a prospective study of 32 infertile men undergoing varicocele ligation. Semen analyses and antisperm antibodies as measured by the immunobead test were performed preoperatively and postoperatively at 3 and 6 months. Of the infertile men with varicocele 28% had a positive immunobead test compared with 0% of normal fertile men. The average total motile sperm count was significantly different (p < 0.05, 2-tailed t test) for 9 varicocele patients with sperm-bound antibody (3.2 x 10(6)) compared with 23 without antibody (8.4 x 10(6)). Postoperatively, 68% of all patients exhibited improved semen parameters, with no change in antibody status in either group. Among the antibody positive group 71% showed an increase in motile sperm per ml. of 2.8 x 10(6) to 17.2 x 10(6) (525% increase, p < 0.05), while in the antibody negative group 67% showed an increase of 3.8 x 10(6) to 24.9 x 10(6) (553% increase, p < 0.05). Our study suggests that there is an increased incidence of sperm-bound immunoglobulin in infertile varicocele patients and an apparent adverse effect on semen parameters in these patients. However, the presence of sperm-bound immunoglobulin did not affect the percentage response to surgical correction, nor can we postulate an immunological mechanism as a major etiological factor in varicocele induced infertility.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-5347
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
151
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1260-2
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8158771-Adult,
pubmed-meshheading:8158771-Autoantibodies,
pubmed-meshheading:8158771-Humans,
pubmed-meshheading:8158771-Immunoglobulins,
pubmed-meshheading:8158771-Infertility, Male,
pubmed-meshheading:8158771-Ligation,
pubmed-meshheading:8158771-Male,
pubmed-meshheading:8158771-Prospective Studies,
pubmed-meshheading:8158771-Sperm Count,
pubmed-meshheading:8158771-Spermatozoa,
pubmed-meshheading:8158771-Varicocele
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Prevalence of sperm bound antibodies in infertile men with varicocele: the effect of varicocele ligation on antibody levels and semen response.
|
| pubmed:affiliation |
Department of Urology, University of Illinois College of Medicine, Michael Reese Hospital and Medical Center, Chicago.
|
| pubmed:publicationType |
Journal Article
|