| pubmed-article:8157610 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0085494 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0022940 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0317708 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0445656 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0317472 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0030958 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:8157610 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:8157610 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8157610 | pubmed:dateCreated | 1994-5-13 | lld:pubmed |
| pubmed-article:8157610 | pubmed:abstractText | The biochemical basis for the acquired or natural resistance of various gram-positive organisms to glycopeptides was studied by high-pressure liquid chromatographic analysis of their peptidoglycan UDP-MurNAc-peptide precursors. In all cases, resistance was correlated with partial or complete replacement of the C-terminal D-Ala-D-Ala-containing UDP-MurNAc-pentapeptide by a new precursor with a modified C terminus. Nuclear magnetic resonance analysis by sequential assignment showed that the new precursor encountered in Enterococcus faecium D366, a strain belonging to the VANB class, which expresses low-level resistance to vancomycin, was UDP-MurNAc-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-lactate, identical to that previously found in the VANA class, which expresses high-level resistance to vancomycin. High-pressure liquid chromatographic analyses, composition determinations, and digestion by R39 D,D-carboxypeptidase demonstrated the exclusive presence of the new precursor in Lactobacillus casei and Pediococcus pentosaceus, which are naturally highly resistant to glycopeptides. The low-level natural resistance of Enterococcus gallinarum to vancomycin was found to be associated with the synthesis of a new precursor identified as a UDP-MurNAc-pentapeptide containing a C-terminal D-serine. The distinction between low and high levels of resistance to glycopeptides appeared also to depend on the presence or absence of a substantial residual pool of a D-Ala-D-Ala-containing UDP-MurNAc-pentapeptide. | lld:pubmed |
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| pubmed-article:8157610 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8157610 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8157610 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8157610 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8157610 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8157610 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:8157610 | pubmed:author | pubmed-author:GutmannLL | lld:pubmed |
| pubmed-article:8157610 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:8157610 | pubmed:author | pubmed-author:GuittetEE | lld:pubmed |
| pubmed-article:8157610 | pubmed:author | pubmed-author:Billot-KleinD... | lld:pubmed |
| pubmed-article:8157610 | pubmed:author | pubmed-author:SabléSS | lld:pubmed |
| pubmed-article:8157610 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8157610 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:8157610 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8157610 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8157610 | pubmed:pagination | 2398-405 | lld:pubmed |
| pubmed-article:8157610 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8157610 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8157610 | pubmed:articleTitle | Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum. | lld:pubmed |
| pubmed-article:8157610 | pubmed:affiliation | Laboratoire de RMN, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France. | lld:pubmed |
| pubmed-article:8157610 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8157610 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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