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rdf:type |
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lifeskim:mentions |
umls-concept:C0016875,
umls-concept:C0021081,
umls-concept:C0021745,
umls-concept:C0033268,
umls-concept:C0034699,
umls-concept:C0205314,
umls-concept:C0205359,
umls-concept:C0205734,
umls-concept:C0301630,
umls-concept:C0679622,
umls-concept:C1155046,
umls-concept:C1280500
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pubmed:issue |
2
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pubmed:dateCreated |
1994-5-17
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pubmed:abstractText |
Diabetes-prone (DP) BB rats spontaneously develop a hyperglycaemic condition which closely resembles human insulin-dependent diabetes mellitus (IDDM), both in terms of clinical and histological features. The incidence of IDDM was significantly reduced when these animals were treated with 2 or 4 mg fusidic acid (FA)/day i.m. from day 30 to day 120 of age. In addition, the mean insulitis score was significantly diminished in the animals treated with FA compared to both vehicle-treated and untreated controls. Finally, 2 mg/day of FA i.m. prevented cell proliferation and interferon-gamma secretion from peripheral blood mononuclear cells upon ex vivo stimulation with concanavalin A. The capacity of FA to substantially reduce the incidence of autoimmune diabetes in a well-known animal model of human IDDM supports previous observations regarding the immunosuppressive properties of FA and its potential use in the treatment of human autoimmune diabetes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1303676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1379130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1420741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1564418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1588978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1588984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1671912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1674091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1702172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1722192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1868757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1899431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1970370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1971174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1973211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-1974010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2017225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2129507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2184355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2491601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2566048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2571881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2671739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2873396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2968199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-2981751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-3111859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-3301238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-3899830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-6129365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-6135075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-6367043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-6607315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8157281-6756938
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8157281-Age Factors,
pubmed-meshheading:8157281-Animals,
pubmed-meshheading:8157281-Autoimmune Diseases,
pubmed-meshheading:8157281-Cell Division,
pubmed-meshheading:8157281-Cells, Cultured,
pubmed-meshheading:8157281-Concanavalin A,
pubmed-meshheading:8157281-Diabetes Mellitus, Type 1,
pubmed-meshheading:8157281-Female,
pubmed-meshheading:8157281-Fusidic Acid,
pubmed-meshheading:8157281-Interferon-gamma,
pubmed-meshheading:8157281-Islets of Langerhans,
pubmed-meshheading:8157281-Male,
pubmed-meshheading:8157281-Rats,
pubmed-meshheading:8157281-Rats, Inbred BB,
pubmed-meshheading:8157281-T-Lymphocytes
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pubmed:year |
1994
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pubmed:articleTitle |
Reduction of spontaneous autoimmune diabetes in diabetes-prone BB rats with the novel immunosuppressant fusidic acid. Effect on T-cell proliferation and production of interferon-gamma.
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pubmed:affiliation |
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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