Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-5-17
|
| pubmed:abstractText |
We report a 3 year-old girl with a myoclonic epilepsy. A fatal hepatic failure occurred after 3 months of valproate (VPA) therapy. In this patient, a defect of cytochrome c oxidase (COX) was demonstrated in her circulating lymphocytes. The enzyme was also found to be deficient in post-mortem liver and in cultured skin fibroblasts. However, a fully functional respiratory chain was found in muscle. VPA administration apparently triggered the hepatic failure, given this patient's background of partial COX deficiency.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0340-6199
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
153
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
133-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8157021-Amino Acids,
pubmed-meshheading:8157021-Child, Preschool,
pubmed-meshheading:8157021-Chromatography, Gas,
pubmed-meshheading:8157021-Cytochrome-c Oxidase Deficiency,
pubmed-meshheading:8157021-Epilepsies, Myoclonic,
pubmed-meshheading:8157021-Fatal Outcome,
pubmed-meshheading:8157021-Female,
pubmed-meshheading:8157021-Hepatic Encephalopathy,
pubmed-meshheading:8157021-Humans,
pubmed-meshheading:8157021-Lactates,
pubmed-meshheading:8157021-Pyruvates,
pubmed-meshheading:8157021-Valproic Acid
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency.
|
| pubmed:affiliation |
Service de Neuropédiatrie, Hôpital d'Enfants, CHU de la Timone, Marseille, France.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|