|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0026377,
umls-concept:C0030935,
umls-concept:C0037633,
umls-concept:C0243072,
umls-concept:C0253946,
umls-concept:C0600115,
umls-concept:C0877853,
umls-concept:C1332714,
umls-concept:C1382100,
umls-concept:C1524075,
umls-concept:C2603343
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-5-19
|
|
pubmed:abstractText |
Solution conformation of CD4 fragment 81-92 TYICEVEDQKEE and two of its benzylated analogues was determined by two-dimensional 1H NMR spectroscopy, distance geometry and simulated annealing techniques. The structures of both benzylated derivatives are similar but are distinct from that of wild-type dodecapeptide. It is concluded from structural analysis that bulky side chain(s) of amino acid(s) at an appropriate position can have a marked effect on the conformation and thus the functions of a peptide.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0006-3002
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
13
|
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pubmed:volume |
1205
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
262-7
|
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8155707-Amino Acid Sequence,
pubmed-meshheading:8155707-Antigens, CD4,
pubmed-meshheading:8155707-Benzene Derivatives,
pubmed-meshheading:8155707-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8155707-Models, Molecular,
pubmed-meshheading:8155707-Molecular Sequence Data,
pubmed-meshheading:8155707-Oligopeptides,
pubmed-meshheading:8155707-Peptide Fragments,
pubmed-meshheading:8155707-Protein Conformation,
pubmed-meshheading:8155707-Solutions
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
Influence of bulky side chains of amino acids on the solution conformation of peptide fragment (81-92) derivatives of CD4, TYICEVEDQKEE, as studied by NMR spectroscopy and molecular modeling.
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|
pubmed:affiliation |
Institute of Chemistry, Academia Sinica, Taipei, Taiwan, R.O.C.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
