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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-5-19
|
| pubmed:abstractText |
Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes. Moreover, our previous studies demonstrated that the pineal neurohormone melatonin (MLT) may enhance IL-2 efficacy. On this basis, a study was started with low-dose IL-2 (3 million U/day subcutaneously for 6 days/week for 4 weeks) plus MLT (50 mg/day orally every day given in the evening) as a first-line therapy of unresectable HCC. The study included 14 patients. Objective tumour regressions were obtained in 5/14 (36%) patients (one complete response, four partial responses), with a median duration of 7+ months. 6 patients had stable disease, while the other 3 progressed. Toxicity was low in all cases. This study shows that the neuroimmunotherapy with low-dose IL-2 plus MLT is a new well-tolerated and effective therapy of advanced HCC.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0959-8049
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30A
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
167-70
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8155391-Adult,
pubmed-meshheading:8155391-Aged,
pubmed-meshheading:8155391-Biopterin,
pubmed-meshheading:8155391-Carcinoma, Hepatocellular,
pubmed-meshheading:8155391-Eosinophils,
pubmed-meshheading:8155391-Female,
pubmed-meshheading:8155391-Humans,
pubmed-meshheading:8155391-Injections, Subcutaneous,
pubmed-meshheading:8155391-Interleukin-2,
pubmed-meshheading:8155391-Leukocyte Count,
pubmed-meshheading:8155391-Liver Neoplasms,
pubmed-meshheading:8155391-Lymphocytes,
pubmed-meshheading:8155391-Male,
pubmed-meshheading:8155391-Melatonin,
pubmed-meshheading:8155391-Middle Aged,
pubmed-meshheading:8155391-Neoplasm Metastasis,
pubmed-meshheading:8155391-Neopterin,
pubmed-meshheading:8155391-Pilot Projects
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma.
|
| pubmed:affiliation |
Divisione di Medicina I, San Gerardo Hospital, Milan, Italy.
|
| pubmed:publicationType |
Journal Article
|