Linked Life Data

815432

Source:http://linkedlifedata.com/resource/pubmed/id/815432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-6-2
pubmed:abstractText
Amino terminal sequence analyses were performed on the H and L chains of the idiotypically related IgMlambda and IgGkappa paraproteins isolated from the sera of a patient, Br. The N-terminal 41 residues of the Br k-chain belonged to the Vkiii subgroup, and L chains derived from BrIgMlambda revealed a blocked N-terminus characteristics of lambda-chains. Comparative sequence analysis of the Br mu- and gamma-chains indicated that, although both possessed an unblocked N-terminal glutamic acid, the respective VH regions belonged to seperate subgroups. The N-terminal 27 residues of the Br mu-chain reflected a typical VHiii subgroup sequence. The Br gamma-chain sequence demonstrated a VHI pattern with an unblocked N-terminus. These structural data stand in contrast to previously reported serologic evidence, which indicated that the BrIgMlambda and BrIgGkappa proteins possessed highly similar Vh-associated idiotypic determinants. Final interpretation of these findings of similar Vh idiotypic determinants expressed by H chains belonging to seperate Vh subgroups must await complete sequence analysis of hypervariable segments of the Br gamma- and mu-chains.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
743-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Comparative studies on monotypic IgMlamba and IgGkappa from an individual patient. II. Amino-terminal sequence analyses.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.