Linked Life Data

8153054

Source:http://linkedlifedata.com/resource/pubmed/id/8153054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-5-11
pubmed:abstractText
Effect of acute inhalation exposure of toluene or halothane anaesthesia on extracellular levels of gamma-aminobutyric acid (GABA) was monitored within the cerebellum of rats by microdialysis. GABA increased during and after exposure to toluene (2000 p.p.m., 2 hr) in contrast, halothane had no noticeable effect on GABA levels. When tetrodotoxin was added to the perfusion medium basal concentrations of GABA decreased to about 74% of control concentrations. Extracellular GABA levels did not increase during exposure to toluene when tetrodotoxin was added to the perfusion medium. The results indicate that toluene increase GABA within the cerebellum by sodium dependent mechanisms, possibly by modulating the neuronal input from the mossy fibers to the cerebellar cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0901-9928
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Acute toluene exposure increases extracellular GABA in the cerebellum of rat: a microdialysis study.
pubmed:affiliation
Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't