| pubmed-article:8152808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C0206364 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C1326631 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8152808 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8152808 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8152808 | pubmed:dateCreated | 1994-5-10 | lld:pubmed |
| pubmed-article:8152808 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8152808 | pubmed:abstractText | To investigate the involvement of protein tyrosine kinases (PTKs) in the growth control of mammary epithelial cells, we have used PCR based cloning to identify PTKs expressed in a mouse mammary epithelial cell line. This approach led to the isolation of two receptor PTKs of the eph-related subfamily; myk-1, a novel member expressed predominantly in lung, heart and mammary gland and myk-2, a close relative of the human eck gene. Northern blot analysis of RNA from mouse mammary glands at different stages of development revealed that myk-1 and myk-2 expression is induced at puberty and differentially regulated during the estrus cycle. myk-1 and myk-2 expression was down-regulated during the pregnancy induced differentiation of the mammary gland. Over-expression of myk-1 and myk-2 was found in the undifferentiated and invasive mammary tumors of transgenic mice expressing the Ha-ras oncogene. In contrast, no elevated expression of either gene could be detected in the well differentiated and non-metastatic mammary tumors of c-myc expressing transgenic mice. These results indicate that myk-1 and myk-2 expression is induced during the proliferation of the mammary gland and down-regulated by its differentiation. | lld:pubmed |
| pubmed-article:8152808 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8152808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8152808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8152808 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8152808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8152808 | pubmed:month | May | lld:pubmed |
| pubmed-article:8152808 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8152808 | pubmed:author | pubmed-author:AlbrechtDD | lld:pubmed |
| pubmed-article:8152808 | pubmed:author | pubmed-author:ZürcherGG | lld:pubmed |
| pubmed-article:8152808 | pubmed:author | pubmed-author:ZiemieckiAA | lld:pubmed |
| pubmed-article:8152808 | pubmed:author | pubmed-author:AndresA CAC | lld:pubmed |
| pubmed-article:8152808 | pubmed:author | pubmed-author:ReidH HHH | lld:pubmed |
| pubmed-article:8152808 | pubmed:author | pubmed-author:BlaschkeR JRJ | lld:pubmed |
| pubmed-article:8152808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8152808 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8152808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8152808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8152808 | pubmed:pagination | 1461-7 | lld:pubmed |
| pubmed-article:8152808 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8152808 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8152808 | pubmed:articleTitle | Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. | lld:pubmed |
| pubmed-article:8152808 | pubmed:affiliation | Laboratory for Clinical and Experimental Research, University of Bern, Switzerland. | lld:pubmed |
| pubmed-article:8152808 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8152808 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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