Linked Life Data

8152541

Source:http://linkedlifedata.com/resource/pubmed/id/8152541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-5-11
pubmed:abstractText
This study provides morphological evidence for the activation of the descending modulatory control by nociceptive afferent pathways. Fos-like immunoreactivity in the spinal dorsal horn is used as an indicator of efficacy of transmission of noxious inputs at this level. Wistar rats were anesthetized with nembutal and the spinal dorsolateral funiculus was transected unilaterally at the level of T11,12. Two days later, an equal volume (0.2 ml) of formalin (5% in saline) was injected into the plantar aspect of two hindpaws. After 1 h of injection, rats were deeply anesthetized and killed for the immunocytochemical examination of Fos-like protein product by using an immunocytochemical technique. The results show that the mean number of Fos protein-like immunoreactive neurons is significantly lower in the superficial laminae and in the neck of the dorsal horn on the side ipsilateral to the intact dorsolateral funiculus than that on the opposite side (i.e. 18.4 +/- 1.0 vs 30.0 +/- 1.3 and 33.9 +/- 0.2 vs 56.8 +/- 1.7, respectively). We conclude that the peripheral noxious inputs (which ascend via the ventral half of the spinal cord in this study) can activate the supraspinal descending inhibitory systems, which in turn suppress the synthesis of Fos-like protein in the related dorsal horn neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:geneSymbol
c-fos
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-304
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effects of descending inhibitory systems on the c-Fos expression in the rat spinal cord during formalin-induced noxious stimulation.
pubmed:affiliation
Department of Neurobiology, Shanxi Medical College, Taiyuan, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't